Since the seventies, positron emission tomography (PET) has become an invaluable medical
molecular imaging modality, especially for cancer diagnosis and the monitoring of its response to
therapy and more recently in direct combination with X-ray computed tomography (CT) or
magnetic resonance (MR).
PET is an incredibly sensitive imaging technique based on electron-positron annihilations and the
nearly coincident detection of the corresponding pairs of photons simultaneously emitted in
opposite directions and electronically collimated along a common line, aka. a line of response
(LOR). Accumulated detections of different annihilation events along various LORs produce
projections of the radioactive concentration volume distribution of a radiopharmaceutical labelled
with a positron emitter radioisotope, such as 18F or 11C. Tomographic image reconstruction from all
the measured projections then leads to the 3D volume representation of the estimated radionuclide
distribution, whose accuracy depends mainly on the ability to associate coincident detections with
actual annihilation photons.
The localization of the emission point of an annihilation pair along a LOR depends on the detection
of the time difference between the two annihilation photons, also known as the time-of-flight (TOF)
difference of the photons, whose accuracy is given by the coincidence time resolution (CTR). This
additional information makes the tomographic inversion problem much less ill-posed, hence
resulting, hence resulting in a better signal-to-noise ratio of the activity measurement. Taking into
account the speed of light, which is approximately 30 cm/ns, a CTR better than 10 picoseconds
FWHM will ultimately allow to obtain a direct 3D volume representation of the estimated activity
distribution of a positron emitting radiopharmaceutical, at the mm level and without the need for
tomographic inversion, thus introducing a quantum leap in PET imaging and quantification.
Moreover, a 10 ps capability will increase effective PET sensitivity, as compared to the state-of-the-art, at least a factor of 16, with the following expected consequences:
- Reduction of the radiation doses of molecular imaging procedures to negligibly low levels;
- Reduction of the synthesized quantity of radiopharmaceutical needed for each examination, and
thus of the relatively high cost currently associated with in-vivo molecular imaging procedures;
- Further extension of the benefit of molecular imaging procedures beyond oncology and
towards cardiovascular, neurological, metabolic, inflammatory, infectious or metabolic disease
(such as diabetes), including in the paediatric, neonatal, and prenatal contexts;
- Maximizing the spatial and temporal resolution of PET based molecular imaging;
- Precise dynamic studies of molecular processes of high interest in pharmacology for screening
and selecting candidate molecules for the next generation of drugs or new applications thereof;
- Potentially further extension of molecular in-vivo imaging to study "systems biology" of the
whole human body through whole-body imaging systems;
- No need for full angular coverage of the patient, opening many new opportunities for PET
While crossing the 10 ps frontier will increase the performance of TOF-PET and lead to the advent
of reconstruction-less PET, it will also permit efficient positron range monitoring in hadrontherapy
(including with protons), improve the performance of Compton camera developed for conventional
scintigraphy and nuclear waste management, and impact both the development of positron
annihilation lifetime spectroscopy (PALS) used in material science and the development of laser
imaging detection and ranging (LIDAR) systems for automotive solutions, e.g. for self-driving cars.
Such a feat will not only require to make progresses on the development of new scintillators (e.g. to
produce enough photons with a minimum time jitter in the first 10 ps after their excitation), but also
on markedly improving light collection, photo-detection and photo-detector electronic readout.
A number of emerging technologies in the domain of scintillating materials, nanotechnologies, solid
state photodetectors and electronics support the idea that crossing the 10 ps frontier is not just a
wild dream and that, as hinted at in preliminary studies 1 an ambitious and coordinated effort could,
lead to a new generation of TOF-PET scanners with unprecedented performance.
TOF back-projection with 10ps FWHM CTR
Hoffman brain phantom simulated analytically without noise
(courtesy: Johan Nuyts, University of Leuven).
Therefore, we intend to launch a 10 ps Challenge to foster the next quantum leap in PET imaging
and make reconstruction-less, high-sensitivity PET scanners a reality, thus paving the way towards
reducing by an order of magnitude the radiation dose (currently 5-7 mSv for a total-body PET), the
scan duration (currently > 10 min), and the scanning cost per patient (currently > 1000 € per scan).
Combining 10 ps TOF-PET with other modalities (X-ray CT, MRI, ultrasound, optical) will further
enable multi-parametric data acquisition and lead to a paradigm shift for in vivo molecular imaging.
This will in turn durably impact societal healthcare challenges not only in oncological disease, but
also in neurodegenerative, inflammatory, infectious or metabolic diseases, from prenatal to old age.
Flash Gordon Prize
A contest would be organized somewhere, e.g. at CERN, 3 years after the
launch of the 10 ps Challenge.
During this contest, teams that would have registered to attend
would demonstrate the CTR performance of their prototype consisting in two detector modules
operating in coincidence. The three best certified achievements would share the prize. Assessments
would be performed using a 68Ge or 22Na point source [the isotope choice to be discussed]
positioned at different positions [the number of positions to be discussed] inside a light-tight box.
The distance between the detector modules would have to be > 10 cm. Positions would be defined
randomly within a range of 10 cm between the two detector modules. Statistics larger than 1000
coincidences would be acquired for each source position. Time calibration of the TOF curves would
be determined from a linear regression through the TOF curve peaks, knowing the source position a
posteriori. CTR would then be estimated by the mean of the CTR measured for each source
Leonard McCoy Prize
This Prize would remain open until a team succeeds in separating - on
an event-to-event basis - 1.6 mm rods of a micro-Derenzo phantom, or until the 10 ps
Image of a slice of a micro-Derenzo phantom type would need to be produced
exclusively by back-projection (without filtering) of TOF data acquired over a predefined time
duration via a pair of detector modules and associated instrumentation (e.g. including both
hardware and software) with a CTR ≤ 10 ps FWHM and an efficiency of at least 10%.
Once a team claims to have achieved a CTR ≤ 10 ps FWHM, a preliminary characterization would
then be performed at the 10 ps Challenge certification platform, using the team's two detection
modules and following the same protocol as defined for the Flash Gordon Prize. In case of success,
10,000 € would be granted to each successful team at this preliminary stage.
The 10 ps Challenge certification platform would be equipped with a mechanical test bench to
allow two detector modules to orbit either together or separately around the phantom. The same
detector modules that would have passed the preliminary characterization test would be used in this
second phase of the Prize. A micro-Derenzo phantom [type and design to be specified more
precisely, but rods are usually 1.2, 1.6, 2.4, 3.2, 4.0 and 4.8 mm] would be filled with a fixed
amount of 18F or 64Cu activity [actual positron emitting isotope to be selected depending on total
expected acquisition time]. The total duration of the data acquisition would also be fixed [overall
duration to be defined, e.g. as long as there would remain some activity in the phantom], whatever
type of orbit would be selected to image the phantom. The imaged slice thickness would be 1.5 mm
[possibly the thickness of the rods placed in a longer phantom; to be discussed]. A contender team
could only once challenge the Leonard McCoy Prize. If a contender team failed to separate the 1.6
mm rods of the micro-Derenzo phantom on the first attempt, they would not be able to run for the
Leonard McCoy Prize again. On the other hand, if a contender team could not succeed at the
preliminary 10 ps FWHM characterization test, they would still remain eligible to compete for the
Leonard McCoy Prize.